Must Reading for Anyone Considering Bio-Identical Hormone Replacement Therapy
My patients frequently ask me why I keep saying that Bio-Identical hormones (especially estrogen and progesterone) are so much safer and more beneficial than synthetic hormones (conjugated equine estrogens and progestins).
An excellent literature review was conducted by Kent Holtorf and titled "The Bio-Identical Hormone Debate: Are Bio-Identical Hormones (Estradiol, Estriol, and Progesterone) Safer or More Efficacious Than Commonly Used Synthetic Versions in Hormone Replacement Therapy". The full text can be downloaded here.
It describes and summarizes 196 studies that investigated Bio-Identical versus synthetic hormones, specifically with a focus on breast cancer and cardiovascular disease. They chose these 2 diseases because of their primary importance and the confusion and controversy surrounding them and synthetic versus Bio-Identical hormones. (If they had also reviewed the literature regarding the many additional significant benefits of Bio-Identical hormones with respect to diseases such as Alzheimer's disease, colon cancer, osteoporosis, macular degeneration, etc., they would have had to review thousands of studies more).
The evidence is substantial and compelling.
Some of the conclusions:
I also encourage you to download this article and read it yourself if you have any concerns or doubts.
Dr. Mark Rosenbloom, M.D.